Gazel (GAZEL)

GAZEL is a general-purpose cohort, an epidemiologic laboratory open to the international scientific community. GAZEL was not constructed to answer a specific question. Instead it was designed to help analyse a wide range of scientific problems and is accessible to the community of researchers specializing in epidemiology. Much research was performed on different topics: aging, cognitive performance, social determinants of health, women's health, traffic accidents, mental health, musculo-skeletal disorders, retirement and so on.

General Information

Study Start Year: 

General Design

Study design: 
Cohort study
General Information on Follow Up (profile and frequency): 

Follow-up is performed through annual self-questionnaires, annual linkage to the company and national health databases and regular health examinations.

Disease endpoints recorded during follow-up: all diseases, through administrative recording and hospital discharges.

Follow-up takes place every year since inception: a questionnaire is sent to all participants, and linkage to the databases is performed.

Recruitment target: 
Target number of participants: 
20 625
Target number of participants with biological samples: 
8 000
Supplementary information about target number of participants: 

The GAZEL study collected the following biospecimens at baseline: 

  • Blood: 8000 participants
  • Plasma: 8000 participants
  • Serum: 8000 participants
  • DNA: 8000 participants


Access to external researchers or third parties provided or foreseen for
Data (questionnaire-derived, measured...): 
Biological samples: 

Marker Paper

Marker paper: 
Zins M, Leclerc A, Goldberg M. The French GAZEL Cohort Study: 20 years of epidemiologic research. Advances in Life Course Research 2009; 14: 135-146.

Supplementary Information

Endpoints (N incident cases)

All diseases were recorded through administrative recording and hospital discharges. The following disease endpoints were recorded during follow-up:

  • Cancer
  • Cardiovascular diseases
  • Neurodegenerative disorders
  • Metabolic disorders

Number of incident cases not available [Feb 2015]; number of cases for all-cause mortality can be provided upon specific request to the study contact.

Study Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.
  • GAZEL Cohort


GAZEL Cohort

In 1989, the GAZEL cohort included 20,625 volunteers workers of the French national utility company (15,011 men and 5,614 women), then aged from 35 to 50 years. This sample was broadly diverse in terms of social, economic, and occupational status, health, and health-related behaviors.

Selection criteria: 
Minimum 35, maximum 50

All France

Sources of recruitment: 
General population:
Volunteer enrolment
Number of participants: 
20 624 participants
Number of participants with biological samples: 
8 000 participants
Data Collection Events:
Gazel Baseline

Letter to eligible subjects; when agreeing...

1989 (January)1989 (December)
Gazel Follow-up

Follow-up takes place every year since...

1990 (January)2014 (January)


Authorization from contributors to the BbmriLpc.IARC Catalogues: 
Marcel GOLDBERG authorised the contribution to BbmriLpc.IARC on Monday, February 3, 2014



Set of exposure variables for the Gazel...