GAZEL is a general-purpose cohort, an epidemiologic laboratory open to the international scientific community. GAZEL was not constructed to answer a specific question. Instead it was designed to help analyse a wide range of scientific problems and is accessible to the community of researchers specializing in epidemiology. Much research was performed on different topics: aging, cognitive performance, social determinants of health, women's health, traffic accidents, mental health, musculo-skeletal disorders, retirement and so on.
Follow-up is performed through annual self-questionnaires, annual linkage to the company and national health databases and regular health examinations.
Disease endpoints recorded during follow-up: all diseases, through administrative recording and hospital discharges.
Follow-up takes place every year since inception: a questionnaire is sent to all participants, and linkage to the databases is performed.
The GAZEL study collected the following biospecimens at baseline:
- Blood: 8000 participants
- Plasma: 8000 participants
- Serum: 8000 participants
- DNA: 8000 participants
Endpoints (N incident cases)
All diseases were recorded through administrative recording and hospital discharges. The following disease endpoints were recorded during follow-up:
- Cardiovascular diseases
- Neurodegenerative disorders
- Metabolic disorders
Number of incident cases not available [Feb 2015]; number of cases for all-cause mortality can be provided upon specific request to the study contact.
- GAZEL Cohort
Letter to eligible subjects; when agreeing to participate volunteers complete a questionnaire and linkage to the database is performed.
Plasma, serum, DNA.
Follow-up takes place every year since inception.
A questionnaire is sent to all participants, and linkage to the databases is performed.
In 1989, the GAZEL cohort included 20,625 volunteers workers of the French national utility company (15,011 men and 5,614 women), then aged from 35 to 50 years. This sample was broadly diverse in terms of social, economic, and occupational status, health, and health-related behaviors.
Letter to eligible subjects; when agreeing...
|1989 (January)||1989 (December)|
Follow-up takes place every year since...
|1990 (January)||2014 (January)|
Set of exposure variables for the Gazel...