The principal objectives of the studies are to:
- Identify genomic regions harboring susceptibility genes influencing common, complex disorders, focusing on cardiovascular, metabolic and inflammatory disorders;
- Enable studies of gene-environmental interactions in common, complex disorders. This will be done with help of the extensive information that exists on environmental exposures and phenotypes in the STR, and with the information gained from genotyping;
- Enable studies on the relationship between biomarkers, gene expression patterns, geno-types and disease, in situations where effects of genotype and disease can be optimally separated, i.e. in disease and phenotype discordant pairs;
- Enable functional studies (on immune function, metabolic function etc) in situations, where biomarkers for disease risk or the disease itself is present, in phenotype concordant or discordant pairs;
- Enable prospective, cohort studies to assess the relative role of disease genes, biomarkers and functional properties (for example immune or metabolic functions) for disease development.