Rotterdam study (Rotterdam study)

The main objective of the Rotterdam Study is to investigate the prevalence and incidence of and risk factors for chronic diseases in the elderly. The chronic diseases of interest are cardiovascular, neurological, locomotor and ophthalmologic diseases. The findings from the Rotterdam Study will hopefully contribute to a better prevention and treatment of chronic diseases in the elderly.

General Information

General Design

Study design: 
Cohort study
General Information on Follow Up (profile and frequency): 

All participants are reexamined every 2-3 years. Morbidity and mortality is registered through general practitioners practises. Events are coded according to the International Classification for Primary Care (ICPC) and tenth edition of the International Classification of Disease (ICD) using clinical information obtained from the general practitioner and hospital discharge records.

Recruitment target: 
Target number of participants: 
15 000
Target number of participants with biological samples: 
15 000
Supplementary information about target number of participants: 

The Rotterdam study collected the following biospecimens at baseline: 

  • Blood: 15 000 participants
  • Saliva: 15 000 participants
  • Urine: 15 000 participants


Access to external researchers or third parties provided or foreseen for
Data (questionnaire-derived, measured...): 
Biological samples: 

Marker Paper

Marker paper: 
The Rotterdam Study: 2014 objectives and design update. Hofman A et al. Eur J Epidemiol. 2013.
Pubmed ID: 

Supplementary Information

Endpoints of particular interest:

  • Neoplasms (C00-D48)    
  • Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89)    
  • Endocrine, nutritional and metabolic diseases (E00-E90)    
  • Mental and behavioural disorders (F00-F99)    
  • Diseases of the nervous system (G00-G99)    
  • Diseases of the eye and adnexa (H00-H59)    
  • Diseases of the circulatory system (I00-I99)    
  • Diseases of the respiratory system (J00-J99)    
  • Diseases of the digestive system (K00-K93)    
  • Diseases of the musculoskeletal system and connective tissue (M00-M99)

Number of incident cases not available.