Norwegian Mother and Child Cohort Study, The (MoBA)

MoBa was initiated in 1999 and is conducted by the Norwegian Institute of Public Health (NIPH). The cohort has enrolled more than 95 000 mothers and include 114 000 children.

MoBa is a family structured cohort study that aims to find causes of diseases and explain variation in health-related traits in a life course span. In addition, the cohort is well equipped to study trajectories of disease. The diseases can occur during pregnancy, in children or in adult men and women. Research questions are related to environmental factors, such as medications, nutrition, infections, work exposure and mental health. Genetic factors as well as the interplay between genes and the environment will be studied.

General Information

Name: 
Norwegian Mother and Child Cohort Study, The
Acronym: 
MoBA
Study Start Year: 
1999
Study End Year: 
2008

General Design

Study design: 
Case-control study
Cohort study
General Information on Follow Up (profile and frequency): 

Questionnaires at week 17, 22, 30 of pregnancy. After birth questionnaires when the children are 6 and 18 month, 3,5,7 and 8 years. Linkage to national health registries data can be done after approval from the ethical committee (and for some registries an approval from the Norwegian Data Inspectorate is also required).

Recruitment target: 
Families (including twin studies, sibships and family based birth cohorts)
Target number of participants: 
284 000
Target number of participants with biological samples: 
234 239
Supplementary information about target number of participants: 

The MoBa study collected the following biospecimens at baseline:

  • Blood
  • Cord blood
  • Plasma
  • DNA

Target number of participants: 284 000 participants

  • 95 000 mothers
  • 75 000 fathers
  • 114 000 children

Target number of participants with biological samples:

  • Pregnant mothers at week 17: 100 000 women
  • Mothers after delivery: 87 000 women
  • Umbilical cord blood: 93 000 children
  • Fathers: 73 000 men

Access

Access to external researchers or third parties provided or foreseen for
Data (questionnaire-derived, measured...): 
Yes
Biological samples: 
Yes

Marker Paper

Marker paper: 
Cohort profile: the Norwegian Mother and Child Cohort Study (MoBa). Magnus P et al. Int J Epidemiol 2006.
Pubmed ID: 

Supplementary Information

Endpoints

Endpoint data not available [Feb 2015]; number of cases can be provided upon specific request to the study contact. The exact number of cases can be obtained through linkage to several Norwegian health registries. This requires a project description and approval for record linkage from the Norwegian Authorities.

Other papers of interest

If biological material is used:
Rønningen KS et al. The biobank of the Norwegian Mother and Child cohort study. Eur J Epidemiol 2006; 21:619-25. PUBMED ID 17031521.

If relevant:
Nilsen RM et al. Self-selection and bias in a large prospective pregnancy cohort in Norway. Paediatr Perinat Epidemiol 2009; 23: 597-608. PUBMED ID 19840297.

If relevant:
The Norwegian Mother and Child Cohort Study, End of Enrolment – Protocol II, Revised October 2012 www.fhi.no/moba-en.

Documents

Study Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.
  • MoBA population

Populations

MoBA population

The Norwegian population of pregnant women, their children and their partners form the target population. The actual sampling frame consists of pregnant women who attended the routine ultrasound appointment around week 17-20 of pregnancy in participating Norwegian hospitals. Only facilities with more than 100 births per year were targeted. The final sample consisted of women and their partners who gave a written consent to participate (about 40% response). Fathers were included from 2000.

Selection criteria: 
Country:
Norway
Supplementary information:

Pregnant women and the father of the unborn child, the child after birth.

Sources of recruitment: 
General population:
Volunteer enrolment
Number of participants: 
284 000 participants
Supplementary information about number of participants: 
  • Pregnant mothers at week 17: 100 000 women
  • Mothers after delivery: 87 000 women
  • Umbilical cord blood: 93 000 children
  • Fathers: 73 000 men
Data Collection Events:
NameDescriptionStartEnd
Baseline (MoBA)

The main source for variables is the self...

1999 (January)2008 (December)

Authorization

Authorization from contributors to the BbmriLpc.IARC Catalogues: 
Charlotte Birke authorised the contribution to BbmriLpc.IARC on Wednesday, February 19, 2014

Datasets

NameDescription
Moba_Questionnaire1

Inventory of exposure variables collected in...

Moba_Questionnaire1

Inventory of exposure variables collected in...

Moba_Questionnaire2

Inventory of exposure data collected in Moba...

Moba_Questionnaire3

Exposure data collected in Moba...

MoBa_Questionnaire4

Inventory of exposure data collected in MoBa...

Moba_Questionnaire5

Exposure data collected in Moba...

Moba_Questionnaire7

Inventory of exposure data collected in Moba...