To study pregnancy complications and diseases in offspring as a function of factors operating in early life, fetal growth, and its determinants. To study especially side effects of medications and infections, and a focus not only on diseases in the period from conception to early childhood, but also on all diseases with a possible origin in the fetal time period.
Danish National Birth Cohort (DNBC)
Permission to follow up the cohort for 20 years, and possible to extend this permission. It is easy to continue follow-up as long as is desired if permissions are given.
Follow-up on questionnaire data 7 and 11 years after enrollment.
Date of last follow-up: 31/06/2014.
The Danish National Birth Cohort study enrolled 100 000 mothers and 60 000 of their children. It collected the following biospecimens at baseline:
- Blood: 100 000 participants (mothers)
- Cord blood: 60 000 participants (their children)
- Plasma: 160 000 participants (mothers and children)
- DNA: 160 000 participants (mothers and children)
ENROLMENT: pregnant women invited to join the study through their GPs, or midwife.
EXPOSURE RECORDING: via computerized phone interviews, occuring four times: at gestational weeks 12 and 30 and when the child is six and 18 months old. At weeks 25-26 of gestation, all participants receive a food frequency questionnaire developed specially to address dietary habits among pregnant women in Denmark.
Endpoints (N incident cases - January 2015)
Diseases of interest: cancer, cardiovascular diseases, neurodegenerative disorders, metabolic disorders, and also asthma, allergy, infections. Most endpoints are registered in the Danish Health care registries which are accessible for researchers.
Head and Neck(C00-C14; C31, C32) = 69
Esophagus (C15) = 5
Stomach (C16) = 17
Colorectal (C18-21) = 165
Liver (C22) = 9
Gallbladder (C23-24) = 5
Pancreas (C25) = 18
Lung (C33-34) = 60
Breast (C50) = 1008
Cervix (C53) = 309
Corpus uteri (C54) = 40
Ovary (C56-57.0) = 121
Prostate (C61) = 1
Total cancers (C00-C97) excluding non-melanoma skin cancer = NA
Acute coronary events = 1268
Stroke = 571
Type II diabetes (E11) = 602
A detailed list of endpoint incident cases can be downloaded from the Documents section.
Supplementary information on access to DNBC's biospecimens and data
Requests for data where individuals may be identified require permission from the Danish Data Protection Agency (Datatilsynet). Requests for biological material need also permission from the Committee on Biomedical Research Ethics (Videnskabsetisk komité).
Conditions under which access can be foreseen:
- Return data to the individual biobank / study in order to increase the scientific value of samples
- Return results to the individual biobank / study to enable feedback to participants (aggregate or individual)
- DNBC population
Enrollment in the Danish National Birth Cohort
Exposure information was collected by computer-assisted telephone interviews with the women twice during pregnancy and when their children were six and 18 months old. Participants were also asked to fill in a self-administered food frequency questionnaire in mid-pregnancy. Furthermore, a biological bank has been set up with blood taken from the mother twice during pregnancy and blood from the umbilical cord taken shortly after birth. Data collection started in 1996 and the project covered all regions in Denmark in 1999. By August 2000, a total of 60,000 pregnant women had been recruited to the study. In October 2002, the goal of 100.000 recruitments was reached.
Follow-up (DNBC) at 7 and 11 year
A 7- and 11-year questionnaire follow-up on the child concerning socioeconomic data, children's diseases, vaccinations, medication, diet and exercise and physical measures.
A large cohort of pregnant Danish women with long-term follow-up of the offspring.
Enrollment in the Danish National...
|1996 (January)||2002 (October)|
|Follow-up (DNBC) at 7 and 11 year|
A 7- and 11-year questionnaire follow-up on...
|2005 (November)||2010 (July)|