Cooperative health research in the region of Augsburg (KORA)

KORA stands for Cooperative Health Research in the Augsburg Region ("Kooperative Gesundheitsforschung in der Region Augsburg"). The focus of KORA is to survey the development and course of chronic diseases, and in particular of myocardial infarction and diabetes mellitus. Risk factors are being analyzed with regard to individual health behavior (as e.g. smoking, diet, or exercise), to the environment (e.g. air pollution, environmental noise) and to genetics. For the purpose of health services research, issues as to utilization and costs of health care are looked into. The KORA research shall provide new approaches in the field of chronic disease prevention and enhance public health care.

General Information

General Design

Study design: 
Case-control study
Cohort study
Cross-sectional prevalence study
Other:

Registry

General Information on Follow Up (profile and frequency): 

Four cross-sectional health surveys S1 to S4 have been performed at five year intervals, each comprising of an independent random sample. The four cross-sectional surveys serve as cohorts for long term follow-up studies and as a pool for nested case-control and case-cohort studies. This pool consists of approximately 18,000 participants with a follow-up duration between 4 and 20 years. The Augsburg myocardial infarction registry was an integral part of the MONICA study and was continued under KORA.

Recruitment target: 
Individuals
Target number of participants: 
18 000
Supplementary information about target number of participants: 

The KORA study collected the following biospecimens at baseline:

  • DNA: 23 880 participants
  • Serum: 23 880 participants
  • Plasma: 15 080 participants
  • Urine: 3 080 participants

 

Access

Access to external researchers or third parties provided or foreseen for
Data (questionnaire-derived, measured...): 
Yes
Biological samples: 
Yes

Marker Paper

Marker paper: 
Holle R et al. KORA--a research platform for population based health research. Gesundheitswesen 2005
Pubmed ID: 

Supplementary Information

Endpoints

Number of prevalent + incident cases for listed ICD-10 codes [March 2015]. Endpoint/case numbers for baseline and follow-up of Survey 3 (S3) & Survey 4 (S4) participants. Baseline and follow-up samples are available for both S3 and S4 populations:

ICD10 Number of cases
C00-D48 total malignant neoplasms and benign neoplasms = 3 954
E00-E07 thyroid disorders = 6 618
E10-E14 diabetes mellitus = 4 914
I10-I15 hypertension = 13 512
I20 Angina pectoris = 1 566
I21 Acute myocardial infarction = 3 348
I50 Heart failure = 2 304
I64 Stroke, not specified as haemorrhage or infarction = 2 484
I70-I79 disorders of arteries etc = 1 038
I80-I89 thrombosis and veins, etc = 8 340
I00-I99 various circulatory endpoints = 20 658

 

Funding Agencies

BMBF - Federal Ministry of Education and Research and Helmholtz Zentrum München

Study Timeline

Each colour in the timeline graph below represents a separate Study Population, while each segment in the graph represents a separate Data Collection Event. Clicking on a segment gives more detailed information on a Data Collection Event.
  • Survey S1 Study population
  • Myocardial infarction registry population
  • Survey S2 Study population
  • Survey S3 Study population
  • Survey S4 Study population

Populations

Survey S1 Study population

Four cross-sectional health surveys S1 to S4 have been performed at five year intervals, each comprising of an independent random sample corresponding to a different study population. 
The four cross-sectional surveys serve as cohorts for long term follow-up studies and as a pool for nested case-control and case-cohort studies. This pool consists of approximately 18,000 participants with a follow-up duration between 4 and 20 years

Selection criteria: 
Age:
Minimum 25, maximum 74
Country:
Germany
Territory:

Augsburg, Southern Germany and surrounding districts

Sources of recruitment: 
General population
Number of participants: 
4 022 participants
Data Collection Events:
NameDescriptionStartEnd
Survey S1

Baseline face to face interview and medical examination.

1984 (January)1985 (December)
Follow-up Examinations of S1-Participants

Coronary heart diseases survey.

1987 (January)1988 (December)
Health Interview Survey 
GEFU1

Postal follow-up of coronary heart diseases.

1997 (January)1998 (December)
Health Interview Survey GEFU2

Postal follow-up quesitionnaire.

2002 (January)2003 (December)

Myocardial infarction registry population

Selection criteria: 
Age:
Minimum 25, maximum 74
Country:
Germany
Territory:

Augsburg, Southern Germany and surrounding districts

Sources of recruitment: 
General population
Supplementary information about number of participants: 

1000 cases each year

Data Collection Events:
NameDescriptionStartEnd
One-Year Follow-up of MI Patients

Postal interviews on post infarction course of disease.

1985 (January)1994 (December)
A22-Study

Interviews on long term survival after MI.

1994 (January)1995 (December)
KORA B

Myocardial infarction family study.

1996 (January)1997 (December)
KORA-A

Diabetes Follow-up study.

1997 (January)1998 (December)
HEI-study

Myocardial infarction and air pollution survey.

1999 (January)2001 (December)
Diabetes Family Study

Diabetes and Genetics survey.

2001 (January)2002 (December)
AIRGENE

Air Pollution and Inflammatory Response in Myocardial Infarction Survivors: Gene-Environment Interaction in a High Risk Group.

2003 (January)2004 (December)

Survey S2 Study population

Four cross-sectional health surveys S1 to S4 have been performed at five year intervals, each comprising of an independent random sample corresponding to a different study population. 
The four cross-sectional surveys serve as cohorts for long term follow-up studies and as a pool for nested case-control and case-cohort studies. This pool consists of approximately 18,000 participants with a follow-up duration between 4 and 20 years

Selection criteria: 
Age:
Minimum 25, maximum 74
Country:
Germany
Territory:

Augsburg, Southern Germany and surrounding districts

Sources of recruitment: 
General population
Number of participants: 
4 940 participants
Data Collection Events:
NameDescriptionStartEnd
Survey S2

Baseline face to face interview and medical examination.

1989 (January)1990 (December)
MEMO study

Memory and Morbidity in Augsburg Elderly survey.

1997 (January)1998 (December)
KORA-A

Diabetes Follow-up study.

1997 (January)1998 (December)
Health Interview Survey 
GEFU1

Postal follow-up of coronary heart diseases.

1997 (January)1998 (December)
Health Interview Survey GEFU2

Postal follow-up quesitionnaire.

2002 (January)2003 (December)

Survey S3 Study population

Four cross-sectional health surveys S1 to S4 have been performed at five year intervals, each comprising of an independent random sample corresponding to a different study population. 
The four cross-sectional surveys serve as cohorts for long term follow-up studies and as a pool for nested case-control and case-cohort studies. This pool consists of approximately 18,000 participants with a follow-up duration between 4 and 20 years

Selection criteria: 
Age:
Minimum 25, maximum 74
Country:
Germany
Territory:

Augsburg, Southern Germany and surrounding districts

Sources of recruitment: 
General population
Number of participants: 
4 856 participants
Data Collection Events:
NameDescriptionStartEnd
Survey S3

Baseline face to face interview and medical examination.

1994 (January)1995 (December)
KORA-A

Diabetes Follow-up study.

1997 (January)1998 (December)
Health Interview Survey 
GEFU1

Postal follow-up of coronary heart diseases.

1997 (January)1998 (December)
KORA-C/D

Asthma & Allergy study.

1997 (January)1999 (December)
Fractures Study

Questionnaire for the subjects practitioner survey, based on anthropometric measurements.

1999 (January)1999 (December)
Health Interview Survey GEFU2

Postal follow-up quesitionnaire.

2002 (January)2003 (December)
KORA F3 (Follow-up of S3)

Standardized computer assisted interview, standardized self-administered questionnaire, physical examination, blood sampling.

2004 (January)2005 (December)

Survey S4 Study population

Four cross-sectional health surveys S1 to S4 have been performed at five year intervals, each comprising of an independent random sample corresponding to a different study population. 
The four cross-sectional surveys serve as cohorts for long term follow-up studies and as a pool for nested case-control and case-cohort studies. This pool consists of approximately 18,000 participants with a follow-up duration between 4 and 20 years

Selection criteria: 
Age:
Minimum 25, maximum 74
Country:
Germany
Territory:

Augsburg, Southern Germany and surrounding districts

Sources of recruitment: 
General population
Number of participants: 
4 261 participants
Data Collection Events:
NameDescriptionStartEnd
Survey S4 (2000)

Standardized interviews, physical examination and blood sampling. 

1999 (January)2001 (December)
KORA/MAGiC-Control

Cardiac arrhythmias and genetics survey.

2002 (January)2003 (December)

Datasets

NameDescription
KORA

Exposure data collected in the KORA study -...